Cardiovascular Outcomes in Patients Initiating First-Line Treatment of Type 2 Diabetes With Sodium–Glucose Cotransporter-2 Inhibitors Versus Metformin: A Cohort Study: Annals of Internal Medicine: Vol 0, No 0

Affiliations:

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts (H.S., R.J.G., E.P.)

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts (S.S.).

Grant Support: By the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School. Dr. Patorno was supported by a career development grant (K08AG055670) from the National Institute on Aging and a research grant from the Patient-Centered Outcomes Research Institute (PCORI; DB-2020C2-20326).

Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M21-4012.

Reproducible Research Statement: Study protocol and Statistical code: Available from Dr. Shin (e-mail, [email protected]harvard.edu). Data set: Available from data vendors through a data use agreement.

Corresponding Author: HoJin Shin, BPharm, PhD, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 1620 Tremont Street (Suite 3030), Boston, MA 02120; e-mail, [email protected]harvard.edu.

Author Contributions: Conception and design: H. Shin, S. Schneeweiss, E. Patorno.

Analysis and interpretation of the data: H. Shin, S. Schneeweiss, R.J. Glynn, E. Patorno.

Drafting of the article: H. Shin.

Critical revision of the article for important intellectual content: H. Shin, S. Schneeweiss, R.J. Glynn, E. Patorno.

Final approval of the article: H. Shin, S. Schneeweiss, R.J. Glynn, E. Patorno.

Provision of study materials or patients: H. Shin, S. Schneeweiss.

Statistical expertise: H. Shin, S. Schneeweiss, R.J. Glynn.

Administrative, technical, or logistic support: H. Shin, E. Patorno.

Collection and assembly of data: H. Shin, S. Schneeweiss, E. Patorno.

This article was published at Annals.org on 24 May 2022.

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